The immense vision of Fabien Pinaud’s treating cancer cells results in Hybrid Nano-Probe. He along with his team developed nano-probe that can result in a simplified treatment of disease that is present at the level of single cell and also for noninvasive detection.
Fabien Pinaud’s is an assistant professor of biological sciences, chemistry and physics and astronomy at USC Dornsife. He is known for the development of methodology strengthening of the biochemical signal on cancer cells surface.
This is novel method combines and accumulates gold nano-particles in living cells utilizing two particles of fluorescent protein in the form of molecular glue. These probes function as amplifiers in the whole process and identify the biomarkers such as mutated or over articulated proteins that are normally found on cancer cells. This ultimately helps to enhance the nano-probes capability to detect dissimilar biomarkers.
The signal enhanced by the mechanism enables the scientists to differentiate the cancer cells from strong cells with the use of a particular laser imaging procedure, Raman spectroscopy.
“Our move reaps the benefits of the actuality that there are two distinct nanoparticles that aren’t active on their own, but are found to active when they amass on cancer cells,” said Pinaud.
With the utilization of molecular glue congregation to design new probes is ordinary practice in biomedical research in the current condition, but a majority of the scientist develop this DNA with protein. While normal optical probes are developed by using DNA assemblies in test tubes, as DNA isn’t a dependable adhesive in live cells. Proteins are more convenient in this case.
In the upcoming research, Scientist will investigate the probability of annihilating individual cancer cell without harming the healthy cells, by heating up the nanoparticles with laser heat.
Pinaud said, “The process of imaging to cells killing is as simple as switching the laser knob that is used.”